Usuku lweHlabathi lweArthritis sisiganeko sokwazisa ngempilo kwihlabathi jikelele esiququzelelwa minyaka le nge-12 ka-Okthobha ukwenza ulwazi malunga nezifo zamathambo kunye ne-musculoskeletal, ifuthe lazo kubomi bomntu kunye nokufundisa abantu ngeempawu kunye namanyathelo othintelo kunye nesikhokelo sokuxilongwa kwangoko ukuze umelane nazo naziphi na ezinye iingxaki. .
Ukubaluleka koSuku lweArthritis lweHlabathi (WAD)
I-arthritis yingxaki edibeneyo yokuvuvukala, echaphazela izicubu ezidibeneyo ezijikeleze umgudu, kunye nezinye izicubu ezidibeneyo, ezibangela intlungu kunye nokuqina.Zingaphezulu kwe-100 iintlobo ze-arthritis ezikhoyo, kodwa ezona zixhaphakileyo yi-osteoarthritis kunye ne-rheumatoid arthritis.Ngenxa yokunqongophala kolwazi kunye nenkxaso, isifo samathambo kunye nemeko enxulumene naso siye saqhwalelisa ubomi obuninzi kwihlabathi jikelele.Alukho unyango oluthile lwe-arthritis, ukhetho lonyango luyahluka ngokusekwe kwiintlobo, ngoko ke kunyanzelekile ukuba uqonde uphawu kunye neempawu kwaye ufumane ukuxilongwa kwangoko ukuze ufumane unyango olufanelekileyo.
Olona hlobo luqhelekileyo lwe-Arthritis
Iintlobo eziqhelekileyo ziquka i-osteoarthritis (OA), i-rheumatoid arthritis (RA), i-psoriatic arthritis (PsA), i-fibromyalgia kunye ne-gout.I-arthritis kunye nezifo ezinxulumene nazo zingabangela intlungu ebuhlungu, eguqula ubomi ngeendlela ezahlukeneyo.
I-arthritis ye-Rheumatoid (RA) sesinye sezifo ezidibeneyo ezivuthayo, eziqhelekileyo kubasetyhini abaneminyaka ephakathi.Ikakhulu ibonakala njengengapheliyo, i-symmetrical, i-polyarthritis eqhubekayo.Ukongeza kokuchaphazela amalungu, kukho izibonakaliso ezininzi ezingaphezulu, ezifana nolusu, amehlo, intliziyo, imiphunga, inkqubo yegazi, njl.
Ukuxhaphaka kwe-RA yi-0.5-1%, kunye nomlinganiselo webhinqa kwindoda ye-3: 1.Kumaxesha ama-4 ukuya ku-5 ngaphezulu kwabasetyhini abangaphantsi kweminyaka engama-50, kodwa emva kweminyaka engama-60 umlinganiselo uba malunga nesi-2 ukuya kwisi-1.Abantu abane-rheumatoid arthritis bahlala benenqanaba eliphezulu le-C-reactive protein (CRP), elinokuthi libonise ubukho benkqubo yokuvuvukala emzimbeni.Olunye uvavanyo lwegazi oluqhelekileyo lujonga izilwa-buhlungu ze-rheumatoid factor (RF) kunye ne-anti-cyclic citrullinated peptide (anti-CCP).
RA(Irheumatoid arthritis)
I-Rheumatoid arthritis sisifo esingapheliyo sokudumba esinokuchaphazela ngaphezu kwamalungu akho kuphela.Kwabanye abantu, imeko inokonakalisa iindidi ezininzi zeenkqubo zomzimba, kuquka ulusu, amehlo, imiphunga, intliziyo kunye nemithambo yegazi.
Ukuphazamiseka kwe-autoimmune, i-rheumatoid arthritis yenzeka xa amajoni akho omzimba ahlasela ngempazamo izicubu zomzimba wakho.
Ngokungafaniyo nomonakalo onxibe kunye nokukrazula kwe-osteoarthritis, i-rheumatoid arthritis ichaphazela umgca wamalungu akho, ibangela ukudumba okubuhlungu okunokuthi ekugqibeleni kubangele ukukhukuliseka kwamathambo kunye nokukhubazeka kwamalungu.
Anti-CCP Anti-Cyclic Citrullinated Peptide Antibody
I-Anti-cyclic citrullinated peptide antibody (Anti-CCP): Yiqhekeza le-polypeptide yeprotheni ye-cyclic polyguanidine kwaye ubukhulu becala i-antibody ye-IgG.I-anti-cyclic citrullinated peptide antibodies ikhutshwa ngokuzenzekelayo yi-B lymphocytes yezigulane ezine-rheumatoid arthritis (RA), ngelixa i-B lymphocytes yezigulane ezinezinye izifo kunye nabantu abaqhelekileyo abazenzeli ngokuzenzekela i-anti-cyclic citrullinated peptide antibodies.Ke ngoko, inobuntununtunu obuphezulu kunye nokuchaneka kwe-rheumatoid arthritis, kwaye sisalathisi esikhethekileyo sokuxilongwa kwangoko kwe-rheumatoid arthritis.
I-Anti-CCP (Anti-cyclic citrullinated peptides) luhlobo lwe-autoantibody: i-antibody esebenza ngokuchasene nezilwa-buhlungu eziqhelekileyo zomzimba wakho.I-Anti-CCP iveliswa ngokuqhelekileyo xa unesifo samathambo.Ezi zithinteli-gazi ziqala ukujolisa kwaye zihlasele izicubu ezisempilweni.
Izibonakaliso zokuqala zokuxilonga i-rheumatoid arthritis: i-anti-cyclic citrullinated antibodies ibonakala kwiminyaka eyi-1-10 ngaphambi kokubonakaliswa kweklinikhi ye-rheumatoid arthritis, efanelekileyo ekuhlolweni komzimba wabantu abaphilileyo kunye nokuxilongwa kwangaphambili kwamaqela asemngciphekweni omkhulu.Ngoku,kukholelwa ukuba uvakalelo lwe-anti-cyclic citrullinated peptide antibodies yokuxilongwa kwe-rheumatoid arthritis yi-50% ukuya kwi-78%, i-specially yi-96%, kwaye izinga elifanelekileyo lezigulane zokuqala lingafikelela kwi-80%.
AeweubomiAni-I-CCP Pindlela
I-Aehealth ye-Anti-CCP (i-Anti-cyclic Citrullinated Peptide Antibody) Uvavanyo olukhawulezayo loMba luthatha indlela ye-Immunofluorescence Assay.
I-Anti-CCP yokufumanisa ikhithi yoluhlu oluyi-10～500 U/mL;i-coefficient yokulungelelaniswa komgca phakathi koxinzelelo lwethiyori kunye nokulinganisa okulinganiselweyo kunokufikelela ku-r≥0.990.Isetyenziswa kunye nohlalutyo lwe-Aehealth Lamuno X immunofluorescence ukukhapha ukuxilongwa kwangoko kunye novavanyo lonyango lwezigulane zamathambo.
I-anti-CCP antibodies ihambelana neeparamitha zomsebenzi we-RA.
Anti-CCP antibodies baqikelela RA umonakalo.
Ixesha lokuposa: Oct-12-2022